Viperin Poisons Viral Replication
نویسندگان
چکیده
منابع مشابه
Viperin: a radical response to viral infection.
One of the first lines of defense of the host immune response to infection is upregulation of interferons, which play a vital role in triggering the early nonspecific antiviral state of the host. Interferons prompt the generation of numerous downstream products, known as interferon-stimulated genes (ISGs). One such ISG found to be either directly induced by type I, II, and III interferons or in...
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by a single A→U point mutation3. Both the benzimidazole derivative and the mutation reduce the production of viral proteins by approximately 80%, likely by preventing formation of the complete 80S eukaryotic ribosome. Hence this small molecule does not function by competitively inhibiting the interaction between the IRES and its target. Instead, it affects IRESdriven viral protein synthesis by ...
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Respiratory syncytial virus (RSV) is an important viral pathogen of otitis media, bronchiolitis, and pneumonia. As infection of the upper airways is a precondition for the development of these diseases, understanding RSV pathogenesis and the host response induced by RSV in this niche may enable the development of novel therapeutic strategies against this virus. We have used a microarray approac...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2018
ISSN: 1931-3128
DOI: 10.1016/j.chom.2018.07.014